COSMIC: Case Study

Finding the best solution

The Technology Transfer Office worked with the Head of COSMIC to propose a sustainability plan aimed at securing the relevance and utility of the database. From the outset, we decided that maximal access to a high quality database for the entire cancer research community was a prerequisite.

We established basic principles to drive our search for a sustainable development model:

-The COSMIC website would be free for all to access, providing a window into the database and allowing anyone interested in the link between cancer and genetic mutation to access the vast array of information available;

-Academic users would have free access to the entire database in a downloadable format, allowing integration with other data sources or the development of new data visualisation tools;

-We would not consider models in which users would access different content dependent on whether they were fee paying or accessing through academic free access.

We explored a number of options, namely: collaborative development with industry, license-controlled access to the database and provision of fee for service. Ahead of recommending a strategy to support long-term growth for COSMIC, we:

- Carried out a benchmarking exercise that involved engaging with a number of academic providers of database resources who had already adopted commercial distribution models;

- Worked with a consultancy firm that had experience of managing Kyoto Encyclopedia of Genes and Genomes‘ commercial licensing on behalf of Kyoto University, for advice on structuring a licensing model;

- Interviewed a large number of companies, primarily from the pharmaceutical and molecular diagnostics sectors to gauge their future use, needs and price point sensitivity. Most of these interviews were conducted face-to-face with bioinformatics and oncology R&D leaders.

Following our research, we decided to focus upon a dual licensing model under which academics would still download the COSMIC database freely while industry users would pay a simple annual subscription fee commensurate with the size of company. Resultant licensing fees are entirely reinvested back into COSMIC, to further improve the website and the database for the entire cancer research community.

Also, we sought tactical or strategic collaborations with industry to help fund and develop new tools and content for the COSMIC database. This means that our industry partners are able to accelerate the development of parts of the database that they are most interested in. This benefits the whole cancer research community as these database improvements are then shared with all its users, as part of the COSMIC package.

In December 2014 the proposed strategy was approved by Genome Research Limited, subject to ongoing review. To test this model and its acceptance in the community a two-year pilot study was launched in March 2015.

The Technology Transfer Office established processes for responding to commercial enquiries, as well as negotiating and managing license contracts. Negotiations with commercial users revealed the diversity of COSMIC commercial users and helped us to create a wider range of licensing contracts to suit the varied needs of our customers.

During a 2-year period, over 100 different organisations took a license to download the COSMIC database. The majority of licenses were either biotech/pharma users whose internal R&D activity includes genomic and bioinformatic platforms or smaller entities providing genomic services principally to the research community (academic, clinical and commercial). The income generated by licensing under the pilot together with industry collaborations, enabled us to double the size of the COSMIC team to a total of 20 individuals by March 2017. The quality of curation, derived manually by PhD scientists with an oncology background, is a unique feature of COSMIC. Extra curators were therefore recruited as a priority to address the immediate challenge of the increasing volume of data in the field.

Collaborations were at the source of two main innovations in COSMIC. Firstly, a new COSMIC-3D feature, developed with Astex Pharmaceuticals, visualising cancer mutations within 3D protein model as a support tool for drug discovery. Secondly, the Cancer Gene Census, developed in partnership with Open Targets, which catalogues over 700 genes implicated in causing cancer together with evidence of each gene’s role in the tumour process (Cancer Hallmarks).

The pilot phase demonstrated both the acceptability of the licensing model to a diverse set of users from industry and the value of industry collaboration in helping us maintain COSMIC as a gold standard database in cancer bioinformatics that is free to academic users.